Pharmacokinetics

You are viewing an older version of this academic item. To access a different version, adjust the year in the field above. For handbooks published prior to 2023, click the "Previous Handbooks" button at the bottom of the page.

Abstract

This subject is based on an understanding of pharmacology, pharmaceutical chemistry and human physiology and examines pharmaceutical, pharmacokinetic and pharmacodynamic principles pertinent to drug action to attain therapeutic objectives. This subject also looks at typical pharmacokinetics and in special cases such as disease states, pregnancy, lactation, paediatrics and geriatrics, taking … For more content click the Read More button below.

Syllabus

This subject will cover the following topics: Absorption, distribution, metabolism and elimination of drugs;Primary pharmacokinetic parameters including: apparent volume of distribution, clearance, and rate constants associated with drug absorption and elimination;IV and extravascular administration of drugs;Concepts of bioequivalence and bioavailability;Therapeutic drug monitoring;Multiple dosage regimes;Linear and non-linear pharmacokinetics;Individualised pharmacokinetics e.g. special … For more content click the Read More button below.

This subject will cover the following topics:

Absorption, distribution, metabolism and elimination of drugs;
Primary pharmacokinetic parameters including: apparent volume of distribution, clearance, and rate constants associated with drug absorption and elimination;
IV and extravascular administration of drugs;
Concepts of bioequivalence and bioavailability;
Therapeutic drug monitoring;
Multiple dosage regimes;
Linear and non-linear pharmacokinetics;
Individualised pharmacokinetics e.g. special cases such as disease states, pregnancy, lactation, paediatrics and geriatrics; and
Principles of drug interactions.

Assumed knowledge

CHM219, PHM231 and the mathematics of exponential/logarithmic functions.

Enrolment restrictions

Pre-requisite